Overview of chronic kidney disease of unknown etiology (CKDu)

Chronic Kidney Disease of undetermined causes (CKDu) is a fatal progressive loss of kidney function that has killed more than 20,000 people in a single decade in Central America alone 1 with over 20,000 more dead in Sri Lanka 2, and uncounted more in other regions.

Currently, LIN is working to understand the scale and scope of the disease in other impacted regions via the DEGREE initiative, improving access to care with colleagues at PASE (Link) and working on effective and scalable workplace interventions with the WE Program.



  1. Ramirez-Rubio O, McClean MD, Amador JJ, Brooks DR. “An epidemic of chronic kidney disease in Central America: an overview” Postgraduate Medical Journal. March 2013 http://www.ncbi.nlm.nih.gov/pubmed/23417684 (not open access).
  2. Jayasumana C, Gunatilake S, Senanayake P. “Glyphosate, hard water and nephrotoxic metals: are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka?” International Journal of Environmental Research and Public Health. February 2014. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945589/pdf/ijerph-11-02125.pdf (open access)